Rheumatoid arthritis: slowing articular inflammation
Early diagnosis to preserve joints
Dr. Marc Lefèvre
Rheumatologist
In simple terms
Methotrexate, biotherapies, JAK inhibitors: the therapeutic revolution of RA.
Chronic inflammation of the joints
Rheumatoid arthritis (RA) affects 0.5% of the population, especially women after 40 years of age. Prolonged morning pain and stiffness (>30 min), symmetrical swelling of small joints (hands, wrists, feet), fatigue.
Early diagnosis
Rheumatoid factor, anti-CCP, CRP, ultrasound or joint MRI. The therapeutic window within the first 3 months is crucial to avoid destruction.
Disease-modifying treatments
Methotrexate: cornerstone, as monotherapy or in combination. Biotherapies (anti-TNF, abatacept, rituximab, tocilizumab) if insufficient response. JAK inhibitors (tofacitinib, baricitinib): effective oral route.
Global approach
Adapted physical activity, physiotherapy, occupational therapy, smoking cessation (smoking aggravates the disease and reduces treatment effectiveness), cardiovascular management (increased risk).
The words explained
Medical terms used above, in everyday language.
- Chronic
- A problem that lasts a long time, usually more than three months, and often comes back.
- Inflammation
- The body's reaction to injury or irritation: redness, swelling, heat or pain.
- Diagnosis
- The moment a doctor identifies which illness is causing your symptoms.
- Cardiovascular
- Related to the heart and blood vessels.
When should you see a doctor?
- Your symptoms last more than a few weeks or keep coming back.
- They get worse quickly, or stop you doing everyday things.
- You notice sudden pain, breathing trouble, fainting or bleeding — seek urgent care.
- You already take medication and want to change anything about it.
This article explains general health information. It does not replace advice from your own doctor.
Frequently asked questions
- What is Rheumatoid arthritis: slowing articular inflammation?
- Methotrexate, biotherapies, JAK inhibitors: the therapeutic revolution of RA.
- What are the main symptoms or signs of Rheumatoid arthritis: slowing articular inflammation?
- Common signs vary from person to person. The article above lists the symptoms to watch for, how they progress, and when they need medical attention.
- When should you see a doctor for Rheumatoid arthritis: slowing articular inflammation?
- See a doctor if symptoms last more than a few weeks, get worse quickly, stop you doing everyday things, or if you notice sudden pain, breathing trouble, fainting or bleeding.
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