Rheumatoid arthritis: slowing articular inflammation

Chronic inflammation of the joints

Rheumatoid arthritis (RA) affects 0.5% of the population, especially women after 40 years of age. Prolonged morning pain and stiffness (>30 min), symmetrical swelling of small joints (hands, wrists, feet), fatigue.

Early diagnosis

Rheumatoid factor, anti-CCP, CRP, ultrasound or joint MRI. The therapeutic window within the first 3 months is crucial to avoid destruction.

Disease-modifying treatments

Methotrexate: cornerstone, as monotherapy or in combination. Biotherapies (anti-TNF, abatacept, rituximab, tocilizumab) if insufficient response. JAK inhibitors (tofacitinib, baricitinib): effective oral route.

Global approach

Adapted physical activity, physiotherapy, occupational therapy, smoking cessation (smoking aggravates the disease and reduces treatment effectiveness), cardiovascular management (increased risk).