Vitiligo: understanding skin depigmentation

A loss of melanocytes

Vitiligo affects 1-2% of the population. The immune system destroys melanocytes, creating symmetrical white patches (hands, face, around orifices). Often associated with other autoimmune diseases (thyroiditis).

Treatments

• Topical corticosteroids and calcineurin inhibitors (tacrolimus): localized forms
• Narrowband UVB phototherapy: reference for extensive forms
• Topical ruxolitinib (JAK inhibitor): approved in 2022, spectacular facial repigmentation
• Melanocyte grafts for stable forms

Living with it

Imperative sun protection, psychological support (often severe aesthetic impact), patient associations.