Infectious Diseases

Long COVID: When Symptoms Persist Months After Infection

Up to 10% of infected people develop prolonged symptoms

Dr. Marie Lefèvre

Internal Medicine Physician

12 min read
Medical illustration of Long COVID: When Symptoms Persist Months After Infection

In simple terms

Debilitating fatigue, brain fog, shortness of breath: long COVID affects the quality of life of millions of people. What do we know today?

Definition of Long COVID

Long COVID, or post-COVID syndrome, refers to the persistence or appearance of symptoms more than 4 weeks after the initial SARS-CoV-2 infection. Estimates suggest that 10 to 20% of infected people could be affected, even after a mild form.

Most frequent symptoms

Fatigue is the most reported symptom (up to 60% of cases), followed by brain fog (concentration and memory problems), shortness of breath, chest pain, palpitations, joint pain, and sleep disorders. Symptoms often fluctuate and can worsen after physical or mental exertion.

Suspected mechanisms

Several hypotheses are being studied: viral persistence in certain tissues, autoimmunity triggered by the infection, microthrombi in small vessels, and autonomic nervous system dysfunction. Research is still ongoing.

Management

There is no specific treatment yet. Progressive rehabilitation, activity pacing, psychological support, and multidisciplinary medical follow-up constitute the current approach. Vaccination seems to reduce the risk of developing long COVID.

The words explained

Medical terms used above, in everyday language.

Symptom
A sign you can feel or see that something is wrong, like pain, tiredness or a rash.
Vaccine
A safe training session for your immune system, so it can fight a germ later.

When should you see a doctor?

  • Your symptoms last more than a few weeks or keep coming back.
  • They get worse quickly, or stop you doing everyday things.
  • You notice sudden pain, breathing trouble, fainting or bleeding — seek urgent care.
  • You already take medication and want to change anything about it.

This article explains general health information. It does not replace advice from your own doctor.

Frequently asked questions

What is Long COVID: When Symptoms Persist Months After Infection?
Debilitating fatigue, brain fog, shortness of breath: long COVID affects the quality of life of millions of people. What do we know today?
What are the main symptoms or signs of Long COVID: When Symptoms Persist Months After Infection?
Common signs vary from person to person. The article above lists the symptoms to watch for, how they progress, and when they need medical attention.
When should you see a doctor for Long COVID: When Symptoms Persist Months After Infection?
See a doctor if symptoms last more than a few weeks, get worse quickly, stop you doing everyday things, or if you notice sudden pain, breathing trouble, fainting or bleeding.